Near-infrared light excited photodynamic anticancer therapy based on UCNP@AIEgen nanocomposite.
Shihui DingWenbo WuTingting PengWen PangPengfei JiangQiuqiang ZhanShuhong QiXunbin WeiBobo GuJie LiuPublished in: Nanoscale advances (2021)
Photodynamic therapy (PDT), a clinically approved cancer treatment strategy, features non-invasiveness, few side-effects, high spatial resolution, etc. The advancement of PDT has been significantly restricted by the penetration depth of the excitation light. Herein, an effective fluorogen, TBD, with aggregation-induced emission characteristics (AIEgen) and high reactive-oxygen-species (ROS) generation efficiency was reported and integrated with a near infrared (NIR) light excitable upconversion nanoparticle (UCNP) to construct NIR light excitable UCNP@TBD nanocomposites. The formed nanocomposite has excellent photostability, good biocompatibility, and efficient ROS generation under NIR light excitation via Förster resonance energy transfer (FRET), enabling NIR light excited PDT. Moreover, the proposed NIR light excited PDT can break the impasse between the penetration depth and excitation volume in conventional PDT, effectively improving the anticancer therapeutic outcome. In vitro cancer cell ablation and in vivo tumor growth inhibition validated that the proposed UCNP@TBD nanocomposite is a promising NIR light excitable PDT agent with great potential for future translational research.
Keyphrases
- photodynamic therapy
- energy transfer
- quantum dots
- fluorescence imaging
- reactive oxygen species
- dna damage
- reduced graphene oxide
- stem cells
- atrial fibrillation
- drug release
- oxidative stress
- single molecule
- gold nanoparticles
- high resolution
- optical coherence tomography
- liquid chromatography
- human health
- mesenchymal stem cells