Topical treatment with a cathepsin G inhibitor, β-keto-phosphonic acid, blocks ultraviolet irradiation-induced basement membrane damage in hairless mouse skin.
Novi KusumaningrumJang-Hee OhDong Hun LeeChang-Yup ShinJee-Hee JangYeon Kyung KimJin Ho ChungPublished in: Photodermatology, photoimmunology & photomedicine (2018)
Our present study showed the possible involvement of CTSG in UV-induced basement membrane damage in skin through topical treatment with a CTSG inhibitor, KPA. Thus, inhibition of CTSG may be a useful strategy for the prevention of UV-induced basement membrane damage and photoaging.