Optimization and Interpretation of Serial QuantiFERON Testing to Measure Acquisition of Mycobacterium tuberculosis Infection.
Elisa NemesVirginie RozotHennie GeldenhuysNicole BilekSimbarashe MabweDeborah AbrahamsLebohang MakhetheMzwandile ErasmusAlana KeyserAsma ToefyYolundi CloeteFrances RatangeeThomas BlauenfeldtMorten RuhwaldGerhard WalzlBronwyn SmithAndre G LoxtonWillem A HanekomJason R AndrewsMaria D LempickiRuth EllisAnn M GinsbergMark HatherillThomas Jens Scribanull nullPublished in: American journal of respiratory and critical care medicine (2017)
Implementation of optimized procedures and a more rigorous QuantiFERON-TB conversion definition (an increase from IFN-γ <0.2 to >0.7 IU/ml) would allow more definitive detection of recent Mtb infection and potentially improve identification of those more likely to develop disease.