Investigation of the combination of anti-PD-L1 mAb with HER2/neu-loaded dendritic cells and QS-21 saponin adjuvant: effect against HER2 positive breast cancer in mice.

Cenk Serhan Ozverel Yigit Uyanikgilİsmail KarabozAyse Nalbantsoy

Published in: Immunopharmacology and immunotoxicology (2020)

Our data suggest that the BM-DC + HER2/neu + QS-21 + anti-PD-L1 vaccine combination paradigm synergistically generates anti-tumor activity and immune responses against HER2 overexpressing breast cancer in mice.

Keyphrases

dendritic cells
immune response
positive breast cancer
high fat diet induced
regulatory t cells
early stage
drug delivery
electronic health record
type diabetes
cancer therapy
toll like receptor
adipose tissue
wild type
machine learning
deep learning
wound healing