Novel breast cancer susceptibility loci under linkage peaks identified in African ancestry consortia.
Heather M Ochs-BalcomLeah PreusZhaohui DuRobert C ElstonCraig C TeerlinkGuochong JiaXingyi GuoQiuyin CaiJirong LongJie PingBingshan LiDaniel O StramXiao-Ou ShuMaureen SandersonGuimin GaoThomas AhearnKathryn L LunettaGary ZirpoliMelissa A TroesterEdward A Ruiz-NarvaezStephen A HaddadJonine FigueroaEsther M JohnLeslie BernsteinJennifer J HuRegina G ZieglerSarah NyanteElisa V BanderaSue A InglesNicholas MancusoMichael F PressSandra L DemingJorge L Rodriguez-GilSong YaoTemidayo O OgundiranOladosu OjengbedeManjeet K BollaJoe DennisAlison M DunningDouglas F EastonKyriaki MichailidouPaul D P PharoahDale P SandlerJack A TaylorQin WangKatie M O'BrienClarice R WeinbergCari M KitaharaWilliam BlotKatherine L NathansonAnselm HennisBarbara NemesureStefan AmbsLara E Sucheston-CampbellJeannette T BensenStephen J ChanockAndrew F OlshanChristine B AmbrosoneOlufunmilayo I Olopadenull The Ghana Breast Health Study TeamDavid V ContiJulie PalmerMontserrat García-ClosasDezheng HuoWei ZhengChristopher HaimanPublished in: Human molecular genetics (2024)
The two chr3 SNPs are upstream to open chromatin ENSR00000710716, a regulatory feature that is actively regulated in mammary tissues, providing evidence that variants in this chr3 region may have a regulatory role in our target organ. Our study provides support for breast cancer variant discovery using prioritization based on linkage evidence.
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