A post-irradiation-induced replication stress promotes RET proto-oncogene breakage.

Fabio HechtLaura ValerioCarlos Frederico Lima GonçalvesMarylin HarinquetRabii Ameziane El HassaniDenise P CarvalhoStephane KoundrioukoffJean-Charles CadoretCorinne Dupuy

Published in: European thyroid journal (2024)

The findings suggest that post-irradiation in the RET gene causes a breakage in the replication fork, which could potentially invade another genomic area, including CCDC6. As a result, this could greatly contribute to the high prevalence of chromosomal RET/PTC rearrangements seen in patients exposed to external radiation.

Keyphrases

copy number
end stage renal disease
newly diagnosed
ejection fraction
radiation induced
peritoneal dialysis
prognostic factors
genome wide
gene expression
diabetic rats
dna methylation
oxidative stress
endothelial cells
heat stress
patient reported
genome wide identification