Distinct genetic alterations and luminal molecular subtype in nested variant of urothelial carcinoma.

Veronika WeyererRebecca WeisserEvgeny A MoskalevFlorian HallerRobert StoehrMarkus EcksteinUlrike ZinnallNadine T GaisaEva CompératAurel PerrenBastian KeckYves AlloryGlen KristiansenBernd WullichAbbas AgaimyArndt HartmannSimone Bertz

Published in: Histopathology (2019)

In summary, NVUC belong to the luminal molecular subtype. Moreover, a subset of NVUC seems to be characterised by mutations of the Wnt and inflammatory pathways, including JAK3 mutations, indicating a different biological background compared to conventional urothelial bladder cancer.

Keyphrases

stem cells
oxidative stress
high grade
genome wide
gene expression
urinary tract