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T cell and dendritic cell interactions in lymphoid organs: More than just being in the right place at the right time.

Milas UgurScott N Mueller
Published in: Immunological reviews (2020)
The initiation of T lymphocyte responses within secondary lymphoid organs involves interactions with different subsets of dendritic cells (DCs). Recent studies have revealed the complexity of microanatomical organization within lymphoid organs. Exactly how T cells and DCs locate each other and the type of cellular interactions required for optimal priming of effector and memory T cell responses are beginning to be unraveled. Here we review advances in our understanding of how T cell priming is choreographed during infections, highlight the importance of cell positioning in this process and discuss how a spectrum of cellular interactions shapes T cell activation and differentiation.
Keyphrases
  • dendritic cells
  • regulatory t cells
  • immune response
  • single cell
  • peripheral blood
  • working memory
  • cell therapy
  • stem cells
  • mesenchymal stem cells