Mechanistic Differences between Torsemide and Furosemide.
Veena S RaoZachary L CoxJuan Betuel Ivey-MirandaDaniel NevilleNatasha BalkcomJulieta Moreno-VillagómezDaniela Ramos-MastacheChristopher MaulionLavanya BellumkondaW H Wilson TangSean P CollinsEric J VelazquezRobert J MentzFrancis Perry WilsonJeffrey M TurnerChristopher S WilcoxDavid H EllisonJames C FangJeffrey M TestaniPublished in: Journal of the American Society of Nephrology : JASN (2024)
We observed no meaningful pharmacokinetic/pharmacodynamic advantages for torsemide vs. furosemide. The greater natriuresis from higher diuretic doses in the torsemide group was offset by greater neurohormonal activation and kidney dysfunction.