Endothelial Cells Induced Progenitors Into Brown Fat to Reduce Atherosclerosis.
Kyoungmin ParkQian LiMatthew D LynesHisashi YokomizoErnesto MaddaloniTakanori ShinjoRonald St-LouisQin LiSayaka KatagiriJialin FuAllen ClermontHyunseok ParkI-Hsien WuMarc Gregory Y YuHetal S ShahYu-Hua TsengGeorge Liang KingPublished in: Circulation research (2022)
Activation of eNOS and endothelial cells by insulin enhanced the differentiation of PPC to BAT and its lipokines and improved systemic bioenergetics and atherosclerosis, suggesting that endothelial dysfunction is a major contributor of energy disequilibrium in obesity.
Keyphrases
- endothelial cells
- high glucose
- type diabetes
- cardiovascular disease
- insulin resistance
- metabolic syndrome
- vascular endothelial growth factor
- adipose tissue
- weight loss
- weight gain
- drug induced
- glycemic control
- diabetic rats
- high fat diet induced
- oxidative stress
- body mass index
- physical activity
- cell proliferation
- pi k akt
- signaling pathway