Transcriptional profiling of identified neurons in leech.
Elizabeth A C Heath-HeckmanShinja YooChristopher WinchellMaurizio PellegrinoJames AngstadtVeronica B LammardoDiana BautistaFrancisco F De-MiguelDavid WeisblatPublished in: BMC genomics (2021)
Our study defines distinct transcriptional profiles for four different neuronal types within the leech CNS, in addition to providing a second ganglionic transcriptome for the species. From these data we identified five gene families that may facilitate the sensory capabilities of these neurons, thus laying the basis for future work leveraging the strengths of the leech system to investigate the molecular processes underlying and linking mechanosensation, cell type specification, and behavior.