Quantification of Right Ventricular Amyloid Burden with 18F-florbetapir PET/CT and its Association with Right Ventricular Dysfunction and Outcomes in Light-Chain Amyloidosis.

Yesh DatarOlivier F ClercSarah A M CuddySirwoo KimAlexandra TaylorJocelyn Canseco NeriDominik C BenzGiada BianchiAndrew J YeeVaishali SanchorawalaFrederick L RubergHeather LandauRonglih LiaoMarie Foley KijewskiMichael Jerosch-HeroldRaymond Y KwongMarcelo F Di CarliRodney H FalkSharmila Dorbala

Published in: European heart journal. Cardiovascular Imaging (2024)

This study shows for the first time that 18F-florbetapir PET/CT identifies early RV amyloid in systemic AL amyloidosis prior to alterations in RV structure and function. Increasing RV amyloid on 18F-florbetapir PET/CT is associated with worse RV structure and function, predicts RV dysfunction and predicts MACE. These results imply a central role for RV amyloid in the pathogenesis of RV dysfunction.

Keyphrases

pet ct
mycobacterium tuberculosis
positron emission tomography
oxidative stress
computed tomography
genome wide
risk factors
drug induced