Vascular Response to Spreading Depolarization Predicts Stroke Outcome.
Nadine Felizitas BinderChaim GlückWilliam MiddlehamMichael AlasoaduraNikolete PranculeviciuteMatthias Tasso WyssJulien ChuquetBruno WeberSusanne WegenerMohamad El AmkiPublished in: Stroke (2022)
Our results show that different types of spreading hyperemia occur spontaneously after the onset of ischemia. Depending on their shape and distribution, they predict severity of injury and outcome. Furthermore, our data show that modulating the hemodynamic response to CSD may be a promising therapeutic strategy to attenuate stroke outcome.