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Biomarkers of sleep-wake disturbance as predictors of cognitive decline and accelerated disease progression.

Aren TuckerTerry E GoldbergHyun Kim
Published in: Expert review of molecular diagnostics (2024)
Routine sleep monitoring in primary care settings has the potential to bolster early detection and treatment of sleep disturbance, and by extension, reduce the risk of dementia. Improving sleep assessment tools, such as wearables, provide scalable alternatives to traditional methods like polysomnography, potentially enabling widespread monitoring of sleep characteristics. Standardized measurement and inclusive participant recruitment are needed to enhance generalizability, while longitudinal studies are essential to understand the interaction between sleep and AD pathology.
Keyphrases
  • sleep quality
  • cognitive decline
  • physical activity
  • primary care
  • mild cognitive impairment
  • depressive symptoms
  • sleep apnea
  • combination therapy