Enhancing CDC and ADCC of CD19 Antibodies by Combining Fc Protein-Engineering with Fc Glyco-Engineering.

Sophia RoßkopfKlara Marie EichholzDorothee WinterbergKatarina Julia DiemerSebastian LutzIra Alexandra MünnichKatja KlauszThies RösnerThomas ValeriusDenis Martin ScheweAndreas HumpeMartin GramatzkiMatthias PeippChristian Kellner

Published in: Antibodies (Basel, Switzerland) (2020)

Fc glyco-engineering and protein-engineering could be combined to enhance ADCC and CDC in CD19 antibodies and may allow the generation of antibodies with higher therapeutic efficacy by promoting two key functions simultaneously.

Keyphrases

cell cycle
protein protein
amino acid
binding protein
small molecule
nk cells