Epigenetic instability caused by absence of CIZ1 drives transformation during quiescence cycles.

Olivia G Dobbs Rosemary H C Wilson Katherine Newling Justin F-X Ainscough Dawn Coverley

Published in: BMC biology (2023)

Our results demonstrate a role for CIZ1 in chromatin condensation on entry to quiescence and explore the consequences of this defect in CIZ1-null cells. Together, the data show that CIZ1's protection of the epigenome guards against genome instability during quiescence cycles. This identifies loss of CIZ1 as a potentially devastating vulnerability in cells that undergo cycles of quiescence entry and exit.

Keyphrases

induced apoptosis
dna methylation
genome wide
cell cycle arrest
gene expression
endoplasmic reticulum stress
dna damage
transcription factor
climate change
oxidative stress
big data
signaling pathway
machine learning
cell proliferation