A randomised, double-blind clinical phase II trial of the efficacy, safety, tolerability and pharmacokinetics of a single dose combination treatment with artefenomel and piperaquine in adults and children with uncomplicated Plasmodium falciparum malaria.

Fiona MacintyreYeka AdokeAlfred B TionoTran Thanh DuongGhyslain Mombo-NgomaMarielle Bouyou-AkotetHalidou TintoQuique BassatSaadou IssifouMarc AdamyHelen DemarestStephan DuparcDidier LeroyBart E LaurijssensSophie BiguenetAfizi KibuukaAntoinette Kitoto TshefuMelnick SmithChanelle FosterIllse LeipoldtPeter G KremsnerBui Quang PhucAlphonse OuedraogoMichael Ramharternull null

Published in: BMC medicine (2017)

ClinicalTrials.gov, NCT02083380 . Registered on 7 March 2014.

Keyphrases

plasmodium falciparum
placebo controlled
double blind
open label
clinical trial
phase ii
phase iii
study protocol
young adults