Intrahepatic cholestasis of pregnancy: Introduction and overview 2024.
William Bill HagueCatherine WilliamsonUlrich BeuersPublished in: Obstetric medicine (2024)
Considerable progress has been made to explain the aetiology of intrahepatic cholestasis of pregnancy (ICP) and of the adverse pregnancy outcomes associated with high maternal total serum bile acids (TSBAs). The reported thresholds for non-fasting TSBA associated with the risk of stillbirth and spontaneous preterm birth can be used to identify pregnancies at risk of these adverse outcomes to decide on appropriate interventions and to give reassurance to women with lower concentrations of TSBA. Data also support the use of ursodeoxycholic acid to protect against the risk of spontaneous preterm birth. A previous history of ICP may be associated with higher rates of subsequent hepatobiliary disease: if there is a suspicion of underlying susceptibility, clinicians caring for women with ICP should screen for associated disorders or for genetic susceptibility and, where appropriate, refer for ongoing hepatology review.
Keyphrases
- preterm birth
- pregnancy outcomes
- pregnant women
- gestational age
- low birth weight
- drug induced
- birth weight
- blood glucose
- high throughput
- electronic health record
- physical activity
- insulin resistance
- big data
- metabolic syndrome
- type diabetes
- gene expression
- copy number
- machine learning
- blood pressure
- deep learning
- body mass index
- skeletal muscle