TL1A regulates adipose-resident innate lymphoid immune responses and enables diet-induced obesity in mice.
Peter TougaardLouise Otterstrøm MartinsenDitte Olsen LützhøftHenrik Elvang JensenMette FlethøjPeter VandenabeeleAnders Elm PedersenSøren SkovAxel Kornerup HansenCamilla Hartmann Friis HansenPublished in: International journal of obesity (2005) (2020)
These findings indicate that TL1A plays an important role in regulating adipose tissue mass and that this role is independent of the gut microbiota. Furthermore, we show that TL1A regulates adipose-resident innate lymphocytes and mitochondria-mediated oxidative stress in eWAT.
Keyphrases
- adipose tissue
- immune response
- insulin resistance
- high fat diet induced
- oxidative stress
- patient safety
- metabolic syndrome
- high fat diet
- type diabetes
- quality improvement
- cell death
- weight loss
- dna damage
- peripheral blood
- toll like receptor
- dendritic cells
- skeletal muscle
- reactive oxygen species
- emergency medicine
- inflammatory response
- endoplasmic reticulum stress