Deposition of Gadolinium in the Central and Peripheral Nervous Systems and Its Effects on Sensory, Cognitive, and Athletic Implications after Multiple Injections of Gadolinium-Based Contrast Agents in Rats.
Xiang YaoJingyi HuGuangsong WangXiaoning LinJin SunGuijiang DongJunlong KangWei FengBowen XieYanlin HuangXinhua TianE ChenPublished in: AJNR. American journal of neuroradiology (2024)
Multiple injections of GBCAs caused gadolinium deposition in the brain, spinal cord, and peripheral nerves, especially in the spinal cords of the gadodiamide group. Gadodiamide led to pain hypersensitivity and decreased muscle power and cognitive ability. For the patients who are hypersensitive to pain and need multiple MRI examinations, we recommend using macrocyclic GBCAs and the lowest dose possible.
Keyphrases
- contrast enhanced
- spinal cord
- neuropathic pain
- chronic pain
- end stage renal disease
- pain management
- magnetic resonance imaging
- ejection fraction
- newly diagnosed
- chronic kidney disease
- magnetic resonance
- computed tomography
- skeletal muscle
- ultrasound guided
- white matter
- peritoneal dialysis
- multiple sclerosis
- patient reported outcomes
- patient reported
- postoperative pain