Estimating tissue-specific TNF mRNA levels prior to anti-TNFα treatment may support therapeutic optimisation in IBD patients.

Jaslin P JamesBoye Schnack NielsenEbbe LangholzMikkel MalhamEstrid HøgdallLene Buhl Riis

Published in: Scandinavian journal of gastroenterology (2023)

Our data indicate that adult PNR have significantly higher TNF mRNA levels than responders. This suggests that higher anti-TNF dose may be considered for IBD patients with high TNF mRNA expression estimates from the start of treatment.

Keyphrases

rheumatoid arthritis
end stage renal disease
newly diagnosed
ejection fraction
machine learning
prognostic factors
big data
ulcerative colitis