Spatially resolved transcriptomics for evaluation of intracranial vessels in a rabbit model: Proof of concept.

Matthew S ZabriskieDaniel L CookeChuanzhuo WangMatthew David Alexander

Published in: Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences (2022)

Intracranial vessels from model rabbits can be processed and analyzed with the Visium SRT platform. Face validity is found in the ability of SRT data to distinguish vessels from parenchymal tissue and differential expression analysis accurately distinguishing arteries from veins. SRT should be considered for future animal model investigations into cerebrovascular diseases.

Keyphrases

optic nerve
single cell
electronic health record
high throughput
big data
machine learning
data analysis
deep learning