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Genetics-guided therapy in neuroendocrine carcinoma: response to BRAF- and MEK-inhibitors.

Lovisa FalkmanAnders SundinBritt SkogseidJohan BotlingYvette BernardoGöran WallinLiang ZhangStaffan WelinIeva LaseKazhan MollazadeganJoakim Crona
Published in: Upsala journal of medical sciences (2024)
-mutated NEC is sensitive to treatment with BRAF- and MEK-inhibitor combination. These results further support that DNA sequencing should be considered as standard of care in NECs to screen for potential treatment targets.
Keyphrases
  • healthcare
  • stem cells
  • high throughput
  • risk assessment
  • circulating tumor
  • wild type
  • cell proliferation
  • replacement therapy
  • cell free
  • quality improvement
  • signaling pathway