[18F]FDG Uptake in Adipose Tissue Is Not Related to Inflammation in Type 2 Diabetes Mellitus.

Melanie ReijrinkStefanie A de BoerInes F AntunesDaan S SpoorHiddo J L HeerspinkMonique E LodewijkMirjam F MastikRonald BoellaardMarcel J W GreuterStan BenjamensRonald J H BorraRiemer H J A SlartJan-Luuk HillebrandsDouwe J Mulder

Published in: Molecular imaging and biology (2020)

In vivo [18F]FDG uptake in VAT from patients with T2DM is positively correlated with adiponectin levels and inversely with IR. Ex vivo [18F]FDG uptake in AT is associated with GLUT4 expression but not with pro-inflammatory markers. The effect of IR should be taken into account when interpreting data of [18F]FDG uptake as a marker for AT inflammation.

Keyphrases

pet ct
pet imaging
positron emission tomography
adipose tissue
oxidative stress
insulin resistance
computed tomography
metabolic syndrome
type diabetes
electronic health record
high fat diet
skeletal muscle
anti inflammatory
deep learning
long non coding rna
glycemic control
artificial intelligence
drug induced