Novel severe traumatic brain injury blood outcome biomarkers identified with proximity extension assay.
Douglas D FraserMichelle ChenAnnie RenMichael R MillerClaudio MartinMark DaleyEleftherios P DiamandisIoannis PrassasPublished in: Clinical chemistry and laboratory medicine (2021)
Targeted proteomics with feature classification and selection distinguished sTBI patients from matched healthy control subjects. Two protein combinations were identified that accurately predicted sTBI patient mortality. Our exploratory findings require confirmation in larger sTBI patient populations.
Keyphrases
- severe traumatic brain injury
- machine learning
- case report
- end stage renal disease
- deep learning
- ejection fraction
- newly diagnosed
- prognostic factors
- traumatic brain injury
- mass spectrometry
- peritoneal dialysis
- cardiovascular events
- type diabetes
- risk factors
- coronary artery disease
- small molecule
- amino acid
- protein protein
- label free
- genetic diversity