Predictive role of circulatory levels of high-mobility group box 1 for radiation pneumonitis in patients with non-small cell lung cancer treated with definitive thoracic radiotherapy.

Shoko IsoyamaKakuhiro YamaguchiNobuki ImanoShinjiro SakamotoYasushi HorimasuTakeshi MasudaShintaro MiyamotoTaku NakashimaHiroshi IwamotoKazunori FujitakaHironobu HamadaYasushi NagataNoboru Hattori

Published in: International journal of clinical oncology (2022)

Higher serum HMGB1 levels were significantly associated with the risk of grade ≥ 3 radiation pneumonitis in patients with lung cancer, and therefore, HMGB1 could be a potential blood biomarker for predicting severe radiation pneumonitis.

Keyphrases

radiation induced
interstitial lung disease
locally advanced
radiation therapy
spinal cord
transcription factor
squamous cell carcinoma
systemic sclerosis
rheumatoid arthritis
risk assessment
climate change
idiopathic pulmonary fibrosis
newly diagnosed