Aberrant DNA methylation of ADAMTS16 in colorectal and other epithelial cancers.

Felix KordowskiJulia KolarovaClemens SchafmayerStephan BuchTorsten GoldmannSebastian MarwitzChristian KuglerSwetlana ScheufeleVolker GasslingChristopher G NémethMario BroschJochen HampeRalph LuciusChristian RöderHolger KalthoffReiner SiebertOle AmmerpohlKarina Reiss

Published in: BMC cancer (2018)

We identified ADAMTS16 as novel gene with cancer-specific promoter hypermethylation in CRC, LC and SCC patients implicating ADAMTS16 as potential biomarker for these tumors. Moreover, our results provide evidence that ADAMTS16 may have tumor suppressor properties.

Keyphrases

dna methylation
end stage renal disease
genome wide
gene expression
chronic kidney disease
ejection fraction
newly diagnosed
copy number
papillary thyroid
young adults
patient reported outcomes
childhood cancer
high resolution