Aberrant DNA methylation of ADAMTS16 in colorectal and other epithelial cancers.
Felix KordowskiJulia KolarovaClemens SchafmayerStephan BuchTorsten GoldmannSebastian MarwitzChristian KuglerSwetlana ScheufeleVolker GasslingChristopher G NémethMario BroschJochen HampeRalph LuciusChristian RöderHolger KalthoffReiner SiebertOle AmmerpohlKarina ReissPublished in: BMC cancer (2018)
We identified ADAMTS16 as novel gene with cancer-specific promoter hypermethylation in CRC, LC and SCC patients implicating ADAMTS16 as potential biomarker for these tumors. Moreover, our results provide evidence that ADAMTS16 may have tumor suppressor properties.