Focused screening reveals functional effects of microRNAs differentially expressed in colorectal cancer.
Danuta SastreJoão BaiochiIldercilio Mota de Souza LimaFelipe Canto de SouzaAmanda Cristina CorveloniCarolina Hassib ThoméVitor Marcel FaçaJosiane Lilian Dos Santos SchiavinatoDimas Tadeu CovasRodrigo Alexandre PanepucciPublished in: BMC cancer (2019)
microRNAs upregulated in CRC tend to induce proliferation in vitro, whereas microRNAs poorly expressed in CRC halt proliferation and induce cell death. We provide novel evidence linking preferential inhibition of the anti-apoptotic MCL-1 L isoform by miR-101-3p and consequent activation of the intrinsic apoptotic pathway as potential mechanisms for its antitumoral activity, likely due to the inhibition of the IL-6/JAK/STAT signaling pathway.