Helicobacter pylori-Derived Outer Membrane Vesicles (OMVs): Role in Bacterial Pathogenesis?
Miroslaw JarzabGernot PosseltNicole Meisner-KoberSilja WesslerPublished in: Microorganisms (2020)
Persistent infections with the human pathogen Helicobacter pylori (H. pylori) have been closely associated with the induction and progression of a wide range of gastric disorders, including acute and chronic gastritis, ulceration in the stomach and duodenum, mucosa-associated lymphoid tissue (MALT) lymphoma, and gastric adenocarcinoma. The pathogenesis of H. pylori is determined by a complicated network of manifold mechanisms of pathogen-host interactions, which involves a coordinated interplay of H. pylori pathogenicity and virulence factors with host cells. While these molecular and cellular mechanisms have been intensively investigated to date, the knowledge about outer membrane vesicles (OMVs) derived from H. pylori and their implication in bacterial pathogenesis is not well developed. In this review, we summarize the current knowledge on H. pylori-derived OMVs.
Keyphrases
- helicobacter pylori
- helicobacter pylori infection
- healthcare
- endothelial cells
- induced apoptosis
- candida albicans
- escherichia coli
- liver failure
- pseudomonas aeruginosa
- biofilm formation
- staphylococcus aureus
- squamous cell carcinoma
- cell cycle arrest
- drug induced
- diffuse large b cell lymphoma
- intensive care unit
- antimicrobial resistance
- cell proliferation
- hepatitis b virus
- radiation therapy
- acute respiratory distress syndrome
- cell death
- endoplasmic reticulum stress
- network analysis
- rectal cancer