Chronic Active Epstein-Barr Virus Infection: The Elucidation of the Pathophysiology and the Development of Therapeutic Methods.
Ayako AraiPublished in: Microorganisms (2021)
Chronic active Epstein-Barr virus infection (CAEBV) is a disease where Epstein-Barr virus (EBV)-infected T- or NK-cells are activated and proliferate clonally. The symptoms of this dual-faced disease include systemic inflammation and multiple organ failures caused by the invasion of infected cells: inflammation and neoplasm. At present, the only effective treatment strategy to eradicate EBV-infected cells is allogeneic stem cell transplantation. Lately, the investigation into the disease's pathogenic mechanism and pathophysiology has been advancing. In this review, I will evaluate the new definition in the 2017 WHO classification, present the advancements in the study of CAEBV, and unfold the future direction.
Keyphrases
- epstein barr virus
- stem cell transplantation
- diffuse large b cell lymphoma
- induced apoptosis
- high dose
- cell cycle arrest
- oxidative stress
- nk cells
- machine learning
- deep learning
- bone marrow
- endoplasmic reticulum stress
- signaling pathway
- low dose
- current status
- physical activity
- combination therapy
- cell death
- replacement therapy
- drug induced