Genotype-stratified treatment for monogenic insulin resistance: a systematic review.

Robert K SempleKashyap Amratlal PatelSungyoung Auhnull nullRebecca J Brown

Published in: Communications medicine (2023)

The evidence guiding genotype-specific treatment of monogenic IR is of low to very low quality. Metreleptin and Thiazolidinediones appear to improve metabolic markers in lipodystrophy, and rhIGF-1 appears to lower HbA1c in INSR-related IR. For other interventions, there is insufficient evidence to assess efficacy and risks in aggregated lipodystrophy or genetic subgroups.

Keyphrases

insulin resistance
type diabetes
metabolic syndrome
dna methylation
high fat diet
genome wide
combination therapy
climate change
copy number
replacement therapy