RNA-binding protein HuR suppresses senescence through Atg7 mediated autophagy activation in diabetic intervertebral disc degeneration.

Zhenxuan ShaoLibin NiSunli HuTianzhen XuZaher MeftahZupo YuNaifeng TianYaosen WuLiaojun SunAimin WuZongyou PanLinwei ChenWeiyang GaoYifei ZhouXiao-Lei ZhangXiangyang Wang

Published in: Cell proliferation (2020)

In conclusion, HuR may suppress senescence through autophagy activation via stabilizing Atg7 in diabetic NP cells; while Atg7, but not HuR, may serve as a potential therapeutic target for DB-IVDD.

Keyphrases

binding protein
induced apoptosis
signaling pathway
endoplasmic reticulum stress
cell death
type diabetes
cell cycle arrest
dna damage
oxidative stress
endothelial cells
wound healing
stress induced
cell proliferation
climate change