17α-Ethinyl estradiol-3-sulfate increases survival and hemodynamic functioning in a large animal model of combined traumatic brain injury and hemorrhagic shock: a randomized control trial.
Andrew R MayerAndrew B DoddJulie G Rannou-LatellaDavid D StephensonRebecca J DoddJosef M LingCarissa J MehosCidney R Robertson-BentaSharvani Pabbathi ReddyRachel E KinslerMeghan S VermillionAndrew P GigliottiVeronik SicardAmy L LloydErik B ErhardtJessica M GillChen LaiVivian A GuedesIrshad H ChaudryPublished in: Critical care (London, England) (2021)
is efficacious in promoting survival and more rapidly restoring cardiovascular homeostasis following polytraumatic injuries in pre-hospital environments (rural and military) in the absence of standard therapies. Poly-therapeutic approaches targeting additional mechanisms (increased hemostasis, oxygen-carrying capacity, etc.) should be considered in future studies.