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Vitamin D receptor gene polymorphism and vitamin D supplementation on clinical/ treatment outcome in tuberculosis: current and future perspectives.

Sonal Sekhar MirajNavya VyasShilia Jacob KurianTejaswini BaralLevin ThomasB Shrikar ReddyMurali MunisamyMithu BanerjeeMahadev Rao
Published in: Expert review of anti-infective therapy (2022)
Although the majority of the findings rule out the benefits of the supplementation, sufficient evidence is available to warrant larger epidemiological research that should be aimed to generate possible interaction among the VDR polymorphism, vitamin D status, and the outcome in TB. We conclude that establishing such an association in different ethnic populations will help design nutrigenomics- or pharmacogenomics-based vitamin D supplementation to develop a personalized medicine approach to flatten the curve of TB disease.
Keyphrases
  • mycobacterium tuberculosis
  • pulmonary tuberculosis
  • adverse drug
  • hiv aids
  • electronic health record