Integrated analysis of DNA methylome and transcriptome reveals SFRP1 and LIPG as potential drivers of ovarian cancer metastasis.

Jiani Yi Mengting Wu Zhihong Zheng Qing Zhou Xufan Li Yan Lu Pengyuan Liu

Published in: Journal of gynecologic oncology (2023)

Many systemic and important epigenetic and transcriptomic alterations occur in the progression of ovarian cancer. In particular, epigenetic silencing of SFRP1 and LIPG is a potential driver event in ovarian cancer metastasis. They can be used as prognostic biomarkers and therapeutic targets for ovarian cancer patients.

Keyphrases

gene expression
dna methylation
single cell
rna seq
genome wide
human health
circulating tumor
single molecule
risk assessment
climate change