Risk factors for mortality in culture-negative neonatal sepsis in Malawi: a propensity score-matched analysis.
Lughano GhambiJames ChiromboTessa de BaatKondwani KawazaPui-Ying Iroh TamPublished in: BMJ paediatrics open (2024)
We conducted a propensity score-matched multivariable regression analysis of 1050 culture-negative neonatal sepsis cases in Malawi, where 160 (15.2%) died. Mortality among neonates with culture-negative sepsis was associated with very low birth weight (adjusted OR (AOR) 12.82, 95% CI 1.23 to 137.49), respiratory distress syndrome (AOR 13.20, 95% CI 2.58 to 83.66), a low Apgar score at 1 min (AOR 3.50, 95% CI 1.21 to 10.72) and at 5 min (AOR 4.77, 95% CI 1.94 to 12.50). Addressing maternal and perinatal factors around health and delivery of care is key to improving outcomes in the context of culture-negative sepsis in neonates from low-income country settings like Malawi.
Keyphrases
- low birth weight
- septic shock
- acute kidney injury
- preterm infants
- intensive care unit
- human milk
- healthcare
- preterm birth
- cardiovascular events
- risk factors
- public health
- palliative care
- pregnant women
- mental health
- type diabetes
- risk assessment
- metabolic syndrome
- coronary artery disease
- health information
- climate change
- adipose tissue
- social media
- pregnancy outcomes
- skeletal muscle
- human health
- chronic pain