Single-cell profiling of bone marrow B cells uncovers early B cell developmental disorders associated with systemic lupus erythematosus.

Chen DongYicheng GuoZechuan ChenTeng LiJuan JiChi SunJing LiHaixia CaoYunfei XiaZhonghui XueXixi GuQian LiangRui ZhaoTing FuJiaqiang MaShan JiangChunmei WuQiong FuGenkai GuoYanfeng BaoHua GuoJunling YangMin XuXiaoming ZhangZizhang ShengZhi-Feng Gu

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2023)

In summary, this study suggests that early B cell loss in BM defines a unique pathological state in a subset of SLE patients which may play an active role in the dysregulated autoimmune responses. This article is protected by copyright. All rights reserved.

Keyphrases

systemic lupus erythematosus
single cell
bone marrow
end stage renal disease
ejection fraction
disease activity
chronic kidney disease
newly diagnosed
rna seq
peritoneal dialysis
multiple sclerosis
mesenchymal stem cells
prognostic factors
rheumatoid arthritis