Thyroid cancers exhibit oncogene-enhanced macropinocytosis that is restrained by IGF1R and promotes albumin-drug-conjugate response.

Hui-Yu Hu Thomas S C Ng Mikyung Kang Ella Scott Ran Li Jeremy M Quintana Dylan Matvey Venkata R Vantaku Ralph Weissleder Sareh Parangi Miles A Miller

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)

These findings identify regulated oncogene-driven macropinocytosis in thyroid cancers and demonstrate the potential of designing albumin-bound drugs to efficiently treat them.

Keyphrases

transcription factor
cancer therapy
drug induced
emergency department
adverse drug
drug delivery
climate change