Pluripotent stem cell-derived skeletal muscle fibers preferentially express myosin heavy-chain isoforms associated with slow and oxidative muscles.
Tania IncittiAlessandro MagliAsher JenkinsKarena LinAmi YamamotoRita C R PerlingeiroPublished in: Skeletal muscle (2020)
Considering oxidative fibers are commonly spared in the context of dystrophic pathogenesis, this feature of PSC-derived myofibers could be advantageous for therapeutic applications.