Immunomodulatory sphingosine-1-phosphates as plasma biomarkers of Alzheimer's disease and vascular cognitive impairment.

Xin Ying ChuaYuek Ling ChaiWee Siong ChewJoyce R ChongHui Li AngPing XiangKaddy CamaraAmy R HowellFederico TortaMarkus R WenkSaima HilalNarayanaswamy VenketasubramanianChristopher P ChenDeron R HerrMitchell Kim Peng Lai

Published in: Alzheimer's research & therapy (2020)

Taken together, our data suggest that plasma d16:1 S1P may be useful as a diagnostic marker for VCI, while the d18:1 to d16:1 S1P ratio is an index of dysregulated S1P-mediated immunomodulation leading to chronic inflammation-associated neurodegeneration and cerebrovascular damage.

Keyphrases

cognitive impairment
oxidative stress
cognitive decline
big data
machine learning
drug induced
artificial intelligence