Gentamicin Administration in Dialysis Patients: Before or After Hemodialysis?

Geeske F GritMarlous L Toren-WielemaPieter J ColinDaniel J Touw

Published in: Therapeutic drug monitoring (2022)

Postdialysis dosing resulted in a low TA of Cmax >8 mg/L; however, predialysis dosing ensured a high TA of Cmax >8 mg/L and acceptable TA of Cmax <20 mg/L, AUC24h >70 mg·h/L, and <120 mg·h/L, which could increase the efficacy of gentamicin. Therefore, clinicians should consider predialysis dosing of gentamicin in patients undergoing intermittent hemodialysis.

Keyphrases

end stage renal disease
chronic kidney disease
peritoneal dialysis
patients undergoing
newly diagnosed
ejection fraction
palliative care
high intensity