Karyopherin α2 is a maternal effect gene required for early embryonic development and female fertility in mice.
Franziska RotherReinhard DeppingElena PopovaStefanie HuegelAriane HeilerEnno HartmannMichael BaderPublished in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology (2024)
The nuclear transport of proteins plays an important role in mediating the transition from egg to embryo and distinct karyopherins have been implicated in this process. Here, we studied the impact of KPNA2 deficiency on preimplantation embryo development in mice. Loss of KPNA2 results in complete arrest at the 2cell stage and embryos exhibit the inability to activate their embryonic genome as well as a severely disturbed nuclear translocation of Nucleoplasmin 2. Our findings define KPNA2 as a new maternal effect gene.
Keyphrases
- pregnancy outcomes
- genome wide
- copy number
- high fat diet induced
- birth weight
- single cell
- genome wide identification
- adipose tissue
- stem cells
- type diabetes
- cell cycle
- gene expression
- dna methylation
- metabolic syndrome
- physical activity
- mesenchymal stem cells
- body mass index
- insulin resistance
- skeletal muscle
- solid state