M2 macrophages promote subconjunctival fibrosis through YAP/TAZ signalling.

Yiwei WangXingchen GengZhihua GuoDandan ChuRuixing LiuBoyuan ChengHaohao CuiChengcheng LiHuayang FengZhanrong Li

Published in: Annals of medicine (2024)

TGF-β1/Smad2/3-YAP/TAZ signalling may be involved in M2-induced fibrotic activities in HTFs. M2 plays a key role in promoting subconjunctival fibrosis and can serve as an attractive target for anti-fibrotic therapeutics.

Keyphrases

transforming growth factor
systemic sclerosis
idiopathic pulmonary fibrosis
epithelial mesenchymal transition
high glucose
diabetic rats
liver fibrosis
oxidative stress
endothelial cells
signaling pathway