A half sandwich Ru(II)- p -cymene nitrite complex selectively induces cell death in cisplatin-resistant malignant melanoma cells.
Yin-Hsuan SunHuey-Ling YouManmath NarwaneRu Xin KoiChai-Lin KaoShyng-Shiou F YuanWei-Ting LiaoTsai-Te LuSodio C N HsuPublished in: Dalton transactions (Cambridge, England : 2003) (2024)
The Ru(II)-nitrite complex, Ru4, is explored to release nitric oxide (NO) under acidic conditions and selectively induce a cytotoxic effect towards SK-MEL-28 cisplatin-resistant malignant melanoma cells. These findings suggest that targeting the tumor-associated pHe level could be an effective strategy for the drug function of Ru(II)-nitrite compounds.