Cobalt(III)-Catalyzed Directed C-7 Selective C-H Alkynylation of Indolines with Bromoalkynes.
Rui-Han NiuJing ZhangRu-Yuan ZhaoQuan-Jian LuoJin-Heng LiBo SunPublished in: Organic letters (2023)
A cobalt(III)-catalyzed directed C-7 alkynylation of indolines with easily accessible bromoalkynes has been developed. The reaction has a broad substrate scope with excellent yields and represents a powerful route to the synthesis of 7-alkynyl-substituted indolines. In addition, the reaction can be extended to the coupling of N -aryl 7-azaindoles, highlighting the synthetic practicability of the strategy.