PITX2C increases the stemness features of hepatocellular carcinoma cells by up-regulating key developmental factors in liver progenitor.

Lingxi JiangXia WangFangfang MaXuelong WangMinmin ShiQian YanMing LiuJuan ChenChaoran ShiXin-Yuan Guan

Published in: Journal of experimental & clinical cancer research : CR (2022)

PITX2C is a newly discovered transcription factor involved in hepatic differentiation and could increase HCC stemness by upregulating key transcriptional factors related to liver development.

Keyphrases

transcription factor
stem cells
epithelial mesenchymal transition
gene expression
dna binding
oxidative stress
signaling pathway