Modular self-assembly system for development of oligomeric, highly internalizing and potent cytotoxic conjugates targeting fibroblast growth factor receptors.
Marta PoźniakNatalia PorębskaKamil JastrzębskiMateusz Adam KrzyścikMarika KucińskaWeronika ZarzyckaAgnieszka BarbachMałgorzata ZakrzewskaJacek OtlewskiMarta MiączyńskaLukasz OpalinskiPublished in: Journal of biomedical science (2021)
Our data implicate that oligomerization of the targeting molecules constitutes an attractive strategy for improvement of the cytotoxicity of conjugates recognizing cancer-specific biomarkers. Importantly, the presented approach can be easily adapted for other tumor markers.