Maternal Cerebrospinal Fluid Glutamate in Response to Variable Foraging Demand: Relationship to Cerebrospinal Fluid Serotonin Metabolites in Grown Offspring.
Jeremy D CoplanNishant K GuptaSarah K FlynnWade J ReinerDavid GaitaSasha L FultonAnna V RozenboymJean E TangThomas B CooperRobyn S KleinPublished in: Chronic stress (Thousand Oaks, Calif.) (2018)
Activation of maternal CSF glutamate in response to VFD-induced allostasis is directly associated with elevations of maternal CSF corticotropin-releasing factor. Maternal CSF glutamate alterations induced by VFD potentially compromise serotonin neurotransmission in grown offspring, conceivably modeling human vulnerability to treatment-resistant mood and anxiety disorders.