Conditioning adhesive contacts between the neutrophils and the endotheliocytes by Staphylococcus aureus.
Svetlana N PleskovaRuslan N KriukovSergey Z BobykAlexey V BoryakovPeter V GorelkinAlexander S ErofeevPublished in: Journal of molecular recognition : JMR (2020)
We have developed a model for evaluating the integral intercellular interactions in the "endotheliocyte-neutrophil" system and have shown the high variability of adhesion contacts in different donors associated with different expression profiles of neutrophils. Two methods (forсe spectroscopy-spectroscopy and scanning ion-conductance microscopy) showed a decrease in the rigidity of the membrane-cytoskeletal complex of neutrophils under the influence of Staphylococcus aureus 2879 M. Adding this strain to the "endotheliocyte-neutrophil" system caused a statistically significant decrease in the adhesion force and adhesion work, which indicates a change in the expression profile and physicochemical properties of membranes of both types of interacting cells (neutrophils and endotheliocytes).
Keyphrases
- staphylococcus aureus
- biofilm formation
- single molecule
- high resolution
- induced apoptosis
- cell adhesion
- pseudomonas aeruginosa
- cell cycle arrest
- escherichia coli
- cell migration
- candida albicans
- high throughput
- solid state
- methicillin resistant staphylococcus aureus
- high speed
- cell death
- endoplasmic reticulum stress
- cell proliferation
- single cell
- pi k akt