Effect of sodium-glucose cotransporter 2 inhibitor on proximal tubular function and injury in patients with type 2 diabetes: a randomized controlled trial.

Bancha SatirapojPattharamon KorkiatpitakOuppatham Supasyndh

Published in: Clinical kidney journal (2019)

This study indicates that dapagliflozin in T2DM patients can decrease the levels of urinary proximal tubular injury biomarkers, thus highlighting its renoprotective effect. SGLT2 inhibitors could prove useful in treating T2DM by protecting against renal tubular injury and may lead to reduced long-term renal outcomes.

Keyphrases

end stage renal disease
ejection fraction
high glucose
newly diagnosed
glycemic control
patient reported outcomes
adipose tissue
insulin resistance
weight loss
diabetic nephropathy